Cancer Cell Therapy M&A

by | Jan 18, 2020

Over the last three years, there have been eight cancer cell therapy M&A deals for advanced first generation and next gen cancer cell therapy companies. Six of them have been completed to date. Data for this analysis was compiled using the DealForma biopharma deals database. We applied initial filters for mergers and acquisitions of companies developing cell therapies for cancer and excluded terminated acquisition offers. From there, we exported the data to Excel, segmented the list by whether the target company’s cell therapy would be considered first generation or next gen, and used pivot tables and charts to do the rest. All data are based on publicly disclosed figures. We invite you to answer interesting questions on biopharma business development and licensing using our data and carefully curated profiles on deals, pipelines, companies, funding, and business executives by visiting dealforma.com to schedule your personalized demo.

As the 38th annual J.P. Morgan Healthcare Conference approached, we used the DealForma deals database to evaluate the recent M&A activity in the cancer cell therapy space. With Yescarta axicabtagene ciloleucel and Kymriah tisagenlecleucel‎ now on the market for two years, cell immunotherapies are one of the newest forms of treatment that helps the immune system fight cancer. We identified eight total cancer cell therapy-focused acquisitions announced in the last three years, six of which have been completed and are highlighted below in order based on deal value. Included in the broader cell therapy analysis that follows were M&A’s, reverse mergers, exercised acquisition options and partnerships with an acquisition option. Terminated acquisition offers were excluded, and Bristol-Myers Squibb’s $74 billion acquisition of Celgene was charted separately.

 

Gilead Sciences acquired Kite Pharma

  • Date Announced: August 28, 2017
  • Total Deal Value: $11.9 billion
  • Target Stage at Acquisition: Phase III
  • Main Asset at Acquisition: Yescarta (chimeric antigen receptor (CAR) T therapy)

 

Celgene acquired Juno Therapeutics

  • Date Announced: January 22, 2018
  • Total Deal Value: $9 billion
  • Target Stage at Acquisition: Phase II
  • Main Asset at Acquisition: JCAR017 (lisocabtagene maraleucel; liso-cel) – CAR-T therapy

 

Astellas Pharma acquired Xyphos Biosciences

  • Date Announced: December 26, 2019
  • Total Deal Value: $665 million
  • Target Stage at Acquisition: Preclinical/IND
  • Main Asset at Acquisition: “convertibleCAR-T” cell product, ACCEL (Advanced Cellular Control through Engineered Ligands) technology platform

 

Gilead, Kite acquired Cell Design Labs

  • Date Announced: December 7, 2017
  • Total Deal Value: $567 million
  • Target Stage at Acquisition: Platform/Discovery
  • Main Asset at Acquisition: synNotch and Throttle technology platforms for CAR-T cells

 

Astellas acquired Universal Cells

  • Date Announced: February 13, 2018
  • Total Deal Value: $102.5 million
  • Target Stage at Acquisition: Preclinical/IND
  • Main Asset at Acquisition: Universal Donor Stem Cell technology

 

Kiadis acquired CytoSen Therapeutics

  • Date Announced: April 17, 2019
  • Total Deal Value: Not Disclosed
  • Target Stage at Acquisition: Phase III
  • Main Asset at Acquisition: ATIR101 (Allodepleted T-cell immunotherapy, discontinued development as of November 2019); CSDT002-NK (natural killer-cell therapy)

 

Two M&A option deals that are yet to be exercised are Kite’s research partnership and an option to acquire Gadeta, and Millennium Pharmaceuticals’ (Takeda Oncology) research partnership and option to acquire GammaDelta Therapeutics.

Using DealForma’s deals database, we also evaluated M&A trends over the past decade of companies developing first and next generation cell therapy, gene therapy, other immuno-oncology therapies, and small molecules for cancer.

Finally, we compared the macro-trends of cancer immunotherapy/cell therapy M&A field with other technology fields including small molecules, diagnostics and gene therapy/vectors.

Want data for your analysis? Want us to do it? Subscribers get both.

Schedule your demo of the DealForma database to see how we help you get better reports done faster.

25,544

Deal Profiles

15,147

Funding Rounds

28,034

Company Profiles

17,936

Product Profiles

119K+

Clinical Trials

3,982

Business Developers

Specifically for Biotech, Pharma, Device, and Diagnostics

Marie Daghlian is a freelance writer and editor who reports on the business of biotechnology and healthcare technologies and on rare diseases for Global Gene’s Rare Daily. She also covers the industry for Big4Bio, a daily newsletter focused on the four major biotech centers in the United States.

More Research by DealForma

January 2022 Top Biopharma Deal: Beam – Pfizer In Vivo Base Editing and Delivery Programs for Rare Diseases

January 2022 Top Biopharma Deal: Beam – Pfizer In Vivo Base Editing and Delivery Programs for Rare Diseases

The top deal upfront for January 2022 was the Beam Therapeutics research partnership with Pfizer with an option to license in vivo base editing programs. Beam will receive $300M up front, up to up to $1.05B in development, regulatory, and sales milestones, plus royalties per licensed program. If Beam opts in to co-develop/co-promote a program, the companies will share cost and profits 65%/35% (Pfizer/Beam).

read more
November 2021 Top Biopharma Deal: Sanofi – Owkin artificial intelligence and federated learning platform to advance Sanofi’s oncology pipeline

November 2021 Top Biopharma Deal: Sanofi – Owkin artificial intelligence and federated learning platform to advance Sanofi’s oncology pipeline

The top deal upfront for November 2021 was the Owkin – Sanofi artificial intelligence and federated learning platform research partnership to advance Sanofi’s oncology pipeline. Owkin will receive a $180M upfront equity investment, $90M in R&D funding over 3 years, and is eligible for additional undisclosed R&D milestones.

read more
October 2021 Top Biopharma Deal: Xencor – Janssen for Plamotamab and XmAb Bispecific Antibodies

October 2021 Top Biopharma Deal: Xencor – Janssen for Plamotamab and XmAb Bispecific Antibodies

The top deal upfront for October 2021 was the Xencor – Janssen deal for plamotamab and XmAb bispecific antibodies and new XmAb B-cell targeting bispecific antibodies for CD20-expressing hematologic malignancies. Xencor will receive $100M in upfront cash, $25M in an upfront equity investment, and is eligible for up to $1.18B in dev., reg., and sales milestones, plus tiered mid-teens to low-twenties royalties.

read more
September 2021 Top Biopharma Deal: REGENXBIO – AbbVie for RBX-314 for wet AMD, diabetic retinopathy

September 2021 Top Biopharma Deal: REGENXBIO – AbbVie for RBX-314 for wet AMD, diabetic retinopathy

The top deal upfront for September 2021 was the REGENXBIO – AbbVie deal for RGX-314 for wet AMD, diabetic retinopathy, and other chronic retinal diseases. REGENXBIO will receive $370M up front and is eligible for up to $1.38B in milestones, plus tiered royalties on net sales of RGX-314 outside the US and 50% of profits in the US.

read more
Top Biopharma Deal April 2021: CRISPR – Vertex for CTX001 for Sickle Cell Disease and Transfusion-Dependent Beta-Thalassemia

Top Biopharma Deal April 2021: CRISPR – Vertex for CTX001 for Sickle Cell Disease and Transfusion-Dependent Beta-Thalassemia

CRISPR Therapeutics and Vertex Pharmaceuticals amended their 2015 deal to develop and commercialize gene editing therapies. This expansion is for Phase I/II CTX001 for severe sickle cell diseases and transfusion-dependent beta-thalassemia. CRISPR will receive $900M up front, up to $200M in milestones upon the first regulatory approval, and a cost/profit split of 40%.

read more

You met on Zoom. Now it's Deal Time.

With thousands of company profiles and a decade of deals specifically in biopharma and medtech, you'll take the guesswork out of deal comps. Schedule your customized demo to see how DealForma helps you win that term sheet with better data.